Science and Technology
What are exosomes?
Exosomes (also known as Extracellular Vesicles) are emerging biomarkers widely regarded as one of the most promising for cancer diagnostics and other diseases.
Exosomes are heterogeneous vesicles naturally released by all cells during their lives, especially tumour cells, and usually carry biologically active molecules, including RNA, lipids and proteins, that can deliver their messages to local or distant targets.
Mursla has developed a novel liquid biopsy platform ExoPheno to interrogate non-invasively disease-specific target exosomes (TEX) and extract life-saving clinical insights that were not available before.
TM
Our exosome liquid biopsy platform: ExoPheno
TM
Our exosome discovery tech: NPDiscover
TEX Isolation
Isolation of TEX with two surface markers via proprietary tagging and release for downstream application
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e.g. exosomes with organ specific and disease specific surface markers
TEX Counting
TEX counting with NPQuantumSense
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Rare subpopulation requiring a low limit of detection system
TEX Sequencing
Cargo analysis
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Liquid chromatography mass spectrometry of TEX protein cargo
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RNA sequencing of TEX RNA cargo
Our exosome validation tech: NPQuantumSense
TEX Quantum Manipulation on Chip
TEX Electrical Sensing/Quantification
On-chip Scalable Format
Method to manipulate tagged exosomes in biofluid via quantum phenomena generated by proprietary nanogap electrodes.
Method to sense classical and non-classical electron transport once target is trapped between nanogap electrodes.
Thousands of nanogap electrodes are stacked on a chip enabling high sensitivity and Moore's Law scalability.