Science 

BIOLOGY

What are disease-specific exosomes?

Exosomes and other extracellular vesicles are heterogeneous vesicles naturally secreted by cells.

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The physiological purpose of generating exosomes can be understood in two ways:  Firstly, remove constituents from cells that may be erroneously produced or are in excess (i.e. due to abnormal functions linked to an existing disease). Secondly, carry bioactive molecules to local or distant recipient cells (to prevent or spread a disease). Therefore, exosomes play an important role in regulating both cellular homeostasis and intercellular communication.

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Exosomes transport intact cellular components including proteins, nucleic acids, lipids and metabolites, either locally or in distant sites via the circulation. Disease-specific exosomes (from disease tissue) are therefore perfect circulating snapshots of disease activities and can offer unexplored clinical insights if they are analysed.

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Our exosome discovery technology

TEX Isolation

Isolation of TEX via proprietary tagging and release for downstream application

  • e.g. exosomes with organ specific and disease specific surface markers 

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TEX Counting

TEX epitope sensing & TEX quantification

  • Rare subpopulation requiring a low limit of detection system

TEX Sequencing

Cargo analysis

  • Liquid chromatography mass spectrometry of TEX protein cargo

  • RNA sequencing of TEX RNA cargo

TECHNOLOGY

ExoPheno  

our exosome liquid biopsy platform

TM

Mursla’s proprietary and integrated platform consists of novel immunocapture-and-release and nanoelectronics technologies. It can interrogate non-invasively disease-specific target exosomes (TEX). 

Our exosome validation technology

TEX Quantum Manipulation on Chip
TEX Electrical Sensing/Quantification
On-chip Scalable Format

Method to manipulate tagged exosomes in biofluid via quantum phenomena generated by proprietary nanogap electrodes.

Method to sense classical and non-classical electron transport once target is trapped between nanogap electrodes.

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Millions of nanogap electrodes are stacked on a chip enabling high sensitivity and Moore's Law scalability.

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