SCIENCE

BIOLOGY

What are disease-specific exosomes?

Exosomes and other extracellular vesicles are heterogeneous vesicles naturally secreted by cells.

The physiological purpose of generating exosomes can be understood in two ways:  Firstly, remove constituents from cells that may be erroneously produced or are in excess (i.e. due to abnormal functions linked to an existing disease). Secondly, carry bioactive molecules to local or distant recipient cells (to prevent or spread a disease). Therefore, exosomes play an important role in regulating both cellular homeostasis and intercellular communication.

Exosomes transport intact cellular components including DNA, RNA, proteins, lipids and metabolites, either locally or in distant sites via the circulation. Tissue-specific exosomes from disease tissue are therefore perfect circulating snapshots of disease activities and offer poorly explored clinical insights into the disease.

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TECHNOLOGY

ExoPheno  
our exosome characterisation platform

TM

ExoPheno™ characterises the multi-omics cargo of exosomes in blood from a selected tissue of origin. It enables the creation of next generation liquid biopsy tests.

It consists of proprietary and patented technologies, which integrate wet lab (validated exosome tissue-of-origin markers, adaptative linker cleavage, pre-analytical multi-omics sequencing workflow and ultrasensitive exosome marker detection systems) and dry lab analysis via machine learning.

ExoPheno overview.png

TECHNOLOGY

ExoPheno  
our exosome characterisation platform

TM

ExoPheno™ characterises the multi-omics cargo of exosomes in blood from a selected tissue of origin. It enables the creation of next generation liquid biopsy tests.

It consists of proprietary and patented technologies, which integrate wet lab (validated exosome tissue-of-origin markers, adaptative linker cleavage, pre-analytical multi-omics sequencing workflow and ultrasensitive exosome marker detection systems) and dry lab analysis via machine learning.

ExoPheno overview.png

PUBLICATIONS

An electro-optical bead-nanochip technology for the ultrasensitive and multi-dimensional detection of small extracellular vesicles and their markers.

Tomás Dias, Ricardo Figueiras, Susana Vagueiro, Renato Domingues, Yu-Hsien Hung, Elnaz Persia, Pierre Arsène. bioRxiv 2022.04.11.487936 (2022)

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Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples 

Nasibeh Karimi, Razieh Dalirfardouei, Tomás Dias, Jan Lötvall, Cecilia Lässer. Journal of Extracellular Vesicles,11, e12213 (2022)

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