SCIENCE

BIOLOGY

What are disease-specific exosomes?

Exosomes and other extracellular vesicles are heterogeneous vesicles naturally secreted by cells.

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The physiological purpose of generating exosomes can be understood in two ways:  Firstly, remove constituents from cells that may be erroneously produced or are in excess (i.e. due to abnormal functions linked to an existing disease). Secondly, carry bioactive molecules to local or distant recipient cells (to prevent or spread a disease). Therefore, exosomes play an important role in regulating both cellular homeostasis and intercellular communication.

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Exosomes transport intact cellular components including proteins, nucleic acids, lipids and metabolites, either locally or in distant sites via the circulation. Disease-specific exosomes (from disease tissue) are therefore perfect circulating snapshots of disease activities and can offer unexplored clinical insights if they are analysed via a single blood draw.

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Our exosome discovery technology

TEX Isolation

Isolation of intact TEX via proprietary tagging and release for downstream application

  • e.g. exosomes with cell specific and disease specific surface markers 

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TEX Counting

TEX epitope sensing & TEX quantification

  • Rare subpopulation requiring a low limit of detection system

  • "You can't fix what you can't measure"

TEX Sequencing

Cargo analysis

  • Liquid chromatography mass spectrometry of TEX protein cargo

  • Sequencing of TEX nucleic acid cargo

TECHNOLOGY

ExoPheno  
our exosome characterisation platform

TM

Mursla’s proprietary and integrated platform consists of novel immunocapture-and-release and nanoelectronics technologies. It can interrogate non-invasively disease-specific target exosomes (TEX). 

Our exosome validation technology

TEX Quantum Manipulation on Chip
TEX Electrical Sensing/Quantification
On-chip Scalable Format

Method to manipulate tagged exosomes in biofluid via quantum phenomena generated by proprietary nanogap electrodes (no chemical binding or alteration).

Method to sense classical and non-classical electron transport once target is trapped between nanogap electrodes (no chemical binding or alteration).

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Millions of nanogap electrodes are stacked on a chip enabling high sensitivity and Moore's Law scalability.

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