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SCIENCE

BIOLOGY

What are tissue-specific Extracellular Vesicles (EVs)?

Extracellular Vesicles (EVs) are heterogeneous vesicles naturally secreted by cells.

The physiological purpose of generating EVs can be understood in two ways: Firstly, remove constituents from cells that may be erroneously produced or are in excess (i.e. due to abnormal functions linked to an existing disease). Secondly, carry bioactive molecules to local or distant recipient cells (to prevent or spread a disease). Therefore, EVs play an important role in regulating both cellular homeostasis and intercellular communication.

Extracellular vesicles transport intact cellular components including DNA, RNA, proteins, lipids and metabolites, either locally or in distant sites via the circulation. Tissue-specific EVs from disease tissue are therefore perfect circulating snapshots of disease activities if they are analysed.

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TECHNOLOGY

ExoPheno  
our exosome characterisation platform

TM

ExoPheno™ characterises the multi-omics cargo of exosomes in blood from a selected tissue of origin. It enables the creation of next generation liquid biopsy tests.

It consists of proprietary and patented technologies, which integrate wet lab (validated exosome tissue-of-origin markers, adaptative linker cleavage, pre-analytical multi-omics sequencing workflow and ultrasensitive exosome marker detection systems) and dry lab analysis via machine learning.

ExoPheno overview.png

TECHNOLOGY

ExoPheno  
our EV characterisation platform

TM

ExoPheno™ analyses the multi-omics cargo of EVs in blood from a selected tissue of origin. It enables the creation of next generation liquid biopsy tests.

It consists of proprietary and patented technologies, which integrate wet lab (validated EV tissue-of-origin markers, adaptative linker cleavage, pre-analytical multi-omics sequencing workflow and ultrasensitive EV marker detection systems) and dry lab analysis via machine learning.

ExoPheno overview.png

PUBLICATIONS

Targeted capture of hepatocyte-derived extracellular vesicles from plasma and subsequent multi-omic analysis reveals potential diagnostic markers of hepatocellular carcinoma

Ricardo Figueiras, Susana Vagueiro, Gillian Reynolds, Elnaz Persia, Raissa Kay, Tomás Dias.

2023 International Society for Extracellular Vesicles, poster number: PF09.09 (2023)

High-yield immunomagnetic isolation of EV sub-populations for downstream applications

Susana Vagueiro, Ricardo Figueiras, Elnaz Persia, Tomás Dias.

2023 International Society for Extracellular Vesicles, oral presentation: LB3.7 (2023)

An electro-optical bead-nanochip technology for the ultrasensitive and multi-dimensional detection of small extracellular vesicles and their markers.

Tomás Dias, Ricardo Figueiras, Susana Vagueiro, Renato Domingues, Yu-Hsien Hung, Elnaz Persia, Pierre Arsène. bioRxiv 2022.04.11.487936 (2022)

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Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples 

Nasibeh Karimi, Razieh Dalirfardouei, Tomás Dias, Jan Lötvall, Cecilia Lässer. Journal of Extracellular Vesicles,11, e12213 (2022)

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