What are liver-derived Extracellular Vesicles (EVs)?
Extracellular Vesicles (EVs) are heterogeneous vesicles naturally secreted by cells.
The physiological purpose of generating EVs can be understood in two ways: Firstly, remove constituents from cells that may be erroneously produced or are in excess (i.e. due to abnormal functions linked to an existing disease). Secondly, carry bioactive molecules to local or distant recipient cells (to prevent or spread a disease). Therefore, EVs play an important role in regulating both cellular homeostasis and intercellular communication.
Extracellular vesicles transport intact cellular components including DNA, RNA, proteins, lipids and metabolites, either locally or in distant sites via the circulation.
Liver-derived EVs are therefore perfect circulating snapshots of the pathological state of liver if they are analysed.
our exosome characterisation platform
ExoPheno™ characterises the multi-omics cargo of exosomes in blood from a selected tissue of origin. It enables the creation of next generation liquid biopsy tests.
It consists of proprietary and patented technologies, which integrate wet lab (validated exosome tissue-of-origin markers, adaptative linker cleavage, pre-analytical multi-omics sequencing workflow and ultrasensitive exosome marker detection systems) and dry lab analysis via machine learning.
our EV characterisation platform
ExoPheno™ analyses the cargo of EVs in blood from a selected tissue of origin, such as liver. It enables the creation of next generation IVD tests.
It consists of proprietary and patented technologies, which integrate wet lab (validated EV tissue-of-origin markers, adaptative linker cleavage, pre-analytical multi-omics sequencing workflow and ultrasensitive EV marker detection systems) and dry lab analysis via machine learning.
Ricardo Figueiras, Susana Vagueiro, Gillian Reynolds, Elnaz Persia, Raissa Kay, Tomás Dias.
2023 International Society for Extracellular Vesicles, poster number: PF09.09 (2023)
Susana Vagueiro, Ricardo Figueiras, Elnaz Persia, Tomás Dias.
2023 International Society for Extracellular Vesicles, oral presentation: LB3.7 (2023)
Tomás Dias, Ricardo Figueiras, Susana Vagueiro, Renato Domingues, Yu-Hsien Hung, Elnaz Persia, Pierre Arsène. bioRxiv 2022.04.11.487936 (2022)
Nasibeh Karimi, Razieh Dalirfardouei, Tomás Dias, Jan Lötvall, Cecilia Lässer. Journal of Extracellular Vesicles,11, e12213 (2022)